TP53 and familial pancreatic carcinoma: It is also clear that additional mutations, such as in p53, can accelerate pancreatic cancer in mouse models, although p53 mutations have pleiotropic effects on both the mutant cells and surrounding microenvironment ranging from metabolic rewiring, DNA damage response, modulation NF-κB inflammatory response, extracellular matrix remodeling, and mediating cell competition (16).