Regarding clinicopathological parameters, this study found that lower levels of E-cad expression are predominantly correlated with deeper invasion, poor differentiation, higher TNM staging, distant metastasis, lymphatic node metastasis, peritoneal metastasis, vascular invasion, lymphatic vessel invasion, greater tumor size, diffuse type of Lauren classification, and Borrmann III+IV. This evidence concerns the gene CDH1 and neoplasm.