SIRT7 and lung carcinoma: To explore this possibility, we performed RNA-sequencing of H1299 lung cancer cells stably expressing scrambled or ARF-targeting shRNA (SI Appendix, Fig. S3 A–C and Dataset S1) as well as of H1299 cells expressing V5-tagged SIRT7 (SI Appendix, Fig. S3 D–F and Dataset S2).