Consistent with the dispensability of SIRT7 catalytic activity for inhibition of ARF, we found that expression of either WT or the SIRT7 HY mutant into SIRT7 KO lung cancer cells stimulates proliferation and anchorage-independent growth to a similar extent (SI Appendix, Fig. S7 C and D). The gene discussed is SIRT7; the disease is lung carcinoma.