MPO and autoimmune polyendocrinopathy: Figure 7E shows representative histology of thrombus sections stained with H&E, as well as Ly6G as a marker of neutrophils. We quantified the number of thrombus-infiltrating Ly6G-positive neutrophils, which were significantly reduced in the mice treated with 2-DG (Figure 7F). When mice were given G6PDi-1, we again found a reduction in APS-associated thrombus weights and circulating MPO-DNA complexes (Supplemental Figure 3, D–F).