TIMP1 and pancreatic neoplasm: This hypothesis is supported by recent research indicating significant gender disparities in cancer, notably in the KPC pancreatic cancer model.25 Studies specifically point to the tissue-inhibitor role of metalloproteinases 1 (TIMP1), which is up-regulated in males and linked to reduced survival and increased liver metastasis, suggesting a complex, sex-specific biologic mechanism that could affect metastatic patterns and outcomes.