On the other hand, the loss of function of DARS [69], RARS [70], KARS [66], HARS1 [67], SARS [68], and NARS2/PARS2 [71] were reported to cause neurological diseases that share ataxic feature, indicating an important role of ARS function in the pathogenesis of ataxia. This evidence concerns the gene RARS1 and cerebellar ataxia.