On the other hand, the loss of function of DARS [69], RARS [70], KARS [66], HARS1 [67], SARS [68], and NARS2/PARS2 [71] were reported to cause neurological diseases that share ataxic feature, indicating an important role of ARS function in the pathogenesis of ataxia. The gene discussed is HARS1; the disease is cerebellar ataxia.