Although PD-L1 is an imperfect biomarker owing to detection methods, non-standardized scoring systems, and tumor types, many studies have shown that high expression of PD-L1 is positively correlated with the PD-1/PD-L1 blockade response rate or OS (Wu et al. 2021; Rui et al. 2019; Ferris et al. 2016; Aguilar et al. 2019). This evidence concerns the gene CD274 and neoplasm.