JAK2 and coronary artery disorder: In addition, AIM2 expressions were positively correlated with systemic inflammatory indicators as an independent risk factor for CAD.<h4>Conclusions</h4>In conclusion, increased AIM2 expression, induced by the IFN-γ/JAK2/STAT1 signal, orientates monocytes to inflammatory status or even pyroptosis through AIM2 inflammasome activation, which is involved in the development of CAD.