Rose and colleagues demonstrated that chronic iron overload reduces voltage dependent L type alpha 1D subunit calcium channel (CaV1.3) expression in the sinoatrial node, atria, atrioventricular node, and proximal ventricular conduction system leading to bradycardia, PR-interval prolongation, heart block, and conduction deficits.4 Here, CACNA1D is linked to Bradycardia.