In addition, associations with major depressive disorder were prominently enriched in genes with high expression specificity for the predicted GABAergic interneuron MGE-N-5 (markers: CRABP1 and ANGPT2; Supplementary figure S6B) and, in contrast to schizophrenia and the other tested phenotypes, the precursor of a distinct dopamine D1 receptor-expressing MSN (LGE-N-5; markers: ERBB4 and TSHZ1; Supplementary figure S5B). The gene discussed is ANGPT2; the disease is schizophrenia.