ESPL1 and infection: As noted above SepA processes Aap, cleaving off the A-domain, and sometimes the lectin domain to leave the B-domain.136 The regulator SarA controls expression of sepA, which is not observed for the other proteases (Figure 3).80 A notable role for SepA is in promoting bacterial survival following neutrophil phagocytosis, contributing to immune evasion and maintenance of infection.137 SepA has also been reported to degrade AMPs and process AtlE132 (Figure 3).