<h4>Aim</h4>To determine variations in allele and genotype frequencies between keratoacanthoma (KA) and common warts (CW), compared with the control group, in three single nucleotide polymorphisms (SNPs) within the TLR2, TLR3, and TLR9 genes.<h4>Methods</h4>This case-control study involved samples from 161 patients with KA, 152 patients with CW, and 469 controls. This evidence concerns the gene TLR3 and keratoacanthoma.