SDC2 and colorectal carcinoma: Existing evidence indicates that methylation of the SDC2 and SFRP2 genes is a valuable diagnostic marker for colorectal cancer; this finding has been validated in the Chinese population.[19, 35] Therefore, herein, CRC‐related methylation sites were screened based on the SFRP2 and SDC2 genes to explore whether the specific methylated CpG sites could be used as diagnostic markers for CRC.