Thus, based on The Cancer Genome Atlas (TCGA) database, a self‐developed bioinformatics analysis was used to prescreen and filter colorectal cancer‐relevant methylation sites detected by the Illumina Infinium MethylationEPIC BeadChip (HM850K) in the SFRP2 and SDC2 genes, which were reported to have high sensitivity for detecting CRC in China.[35] This analysis aimed to improve the efficiency of site selection. The gene discussed is SFRP2; the disease is colorectal cancer.