The methylation of SFRP2, BMP3, NDRG4, and TFPI2 has been reported to be useful diagnostic markers for CRC, and multitarget stool tests are usually used to improve the diagnostic performance of CRC.[43, 44, 45, 46] The sensitivities were 86.2%–93.4% for CRC and 46.2%–61.5%for AA, with the specificity ranging from 89.1%– 94.3% in the published research (Table S5, Supporting Information).[8, 17, 18] Like in these previous studies, we also found that SFRP2‐1, when combined with SDC2‐6, improved the diagnostic sensitivity. This evidence concerns the gene BMP3 and colorectal carcinoma.