Existing evidence indicates that methylation of the SDC2 and SFRP2 genes is a valuable diagnostic marker for colorectal cancer; this finding has been validated in the Chinese population.[19, 35] Therefore, herein, CRC‐related methylation sites were screened based on the SFRP2 and SDC2 genes to explore whether the specific methylated CpG sites could be used as diagnostic markers for CRC. This evidence concerns the gene SDC2 and colorectal cancer.