Palmitate and other saturated free fatty acids have been previously associated with impaired insulin secretion, impaired insulin sensitivity, and glucose intolerance35 as well as levels of palmitate are positively correlated with levels of HbA1c in T2D patients.36 Therefore, our results could be explained by the higher initial HbA1c levels within the Responders cohort. The gene discussed is INS; the disease is type 2 diabetes mellitus.