Ultimately, by conducting experiments on cells and animals, we were able to show how IRX5 impacts the aggressive characteristics of thyroid cancer cells and its influence on macrophages within the immune system of thyroid cancer.<h4>Results</h4>In 11 malignant tumors, including PTC, IRX5 is overexpressed and associated with a poor prognosis. The gene discussed is IRX5; the disease is thyroid cancer.