Additionally, the <i>EGFR</i> ligands <i>AREG</i> and <i>EREG</i> have shown associations with response to anti-EGFR therapy and improved progression-free survival in colorectal carcinoma.<h4>Materials and methods</h4>We investigated the prognostic significance of <i>EGFR</i>, <i>AREG</i>, and <i>EREG</i> in MIBC. The gene discussed is EGFR; the disease is colorectal carcinoma.