Various approaches have been employed to minimize the incidence of OHSS, including the application of a minimal dose and duration of gonadotropin to achieve optimal follicular growth implementing a step-up (increasing) protocol, applying a gonadotropin releasing hormone (GnRH)-antagonist protocol, triggering with GnRH-agonist in the GnRH-antagonist protocol, freezing all embryos as a policy, coasting and utilizing in vitro maturation (7–9). The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.