In addition, researchers explored the susceptibility genes of GDM through case-control studies and found that genes such as TCF7L2, VDR, and IGF2BP2 serve multiple functions such as β-cell function, insulin secretion, peripheral insulin resistance, glucose metabolism, and oxidative stress, conferring genetic susceptibility to GDM (Wei et al., 2021). The gene discussed is TCF7L2; the disease is gestational diabetes.