To achieve this objective, two MET‐mediated acquired resistance NSCLC cell lines with EGFR‐activating mutations were established through lentivirus stable transfection herein, resulting in the overexpression of MET in PC‐9 cells (EGFR exon 19 deletion, PC9 OE) and NCI‐H1975 cells (EGFR T790M mutation, NCI‐H1975 OE). Here, EGFR is linked to non-small cell lung carcinoma.