The proportion of naive T cells showed a negative trend association with the 17‐item Hamilton Depression Rating Scale (HAMD‐17, r = −0.22, p = 0.39) or 16‐item Quick Inventory of Depressive Symptomology–Self‐Report (QIDS, r = −0.37, p = 0.10) scores, which was not seen in GZMH+CD8+ Tm cells (Figure 2B–D,F–H). This evidence concerns the gene CD8A and major depressive disorder.