Altered lipids promote adverse interactions between hepatocytes and Kupffer cells.[70] We confirmed that hypoxia‐induced hepatic damage stimulates macrophage inflammation, accompanied by upregulation of PRDM1 expression and activation of the NF‐κB signaling pathway, through hypoxia‐stimulated, IUGR‐induced hepatic injury in co‐culture cell experiments. This evidence concerns the gene NFKB1 and fetal growth restriction.