SOAT1 and metabolic disease: By integrating functional enrichment and trajectory phases (Table S9, Supporting Information), a transition was identified starting with the activation of monocytes via the JAK‐STAT signaling pathway and adipocytokine, progressing through an intermediate proliferative state characterized by cDCs, followed by a phagosomal state featuring pDCs and some Kupffer cells, and culminating in a metabolic disorder and inflammatory state characterized by Kupffer cells (Figure 4d).