As widely acknowledged, the resilient and immune‐rich environment of the liver supports regional and systemic homeostasis, enabling hepatic regeneration.[51] However, the delicate equilibrium of liver homeostasis is perturbed by the process of intrauterine programming caused by an unfavorable intrauterine environment.[52] It is well‐established that IUGR leads to intrauterine hypoxia, a fact validated by data showing an enrichment of the HIF‐1 signaling pathway and highlighting the expression of EPO and GAPDH during IUGR. This evidence concerns the gene EPO and fetal growth restriction.