Tumor hypoxia contributes significantly to resistance against ferroptosis,[22] due to the stabilization of solute carrier family 7 member 11 (SLC7A11) mRNA, a gene vital for cystine transport and glutathione (GSH) synthesis,[23] facilitated by hypoxia‐inducible factor 1α (HIF‐1α).[24] Under US irradiation, NPs‐Ce6 emits continuous red light, inducing prolonged PCC photosynthesis, alleviating tumor hypoxia, and improving SDT. Here, HIF1A is linked to neoplasm.