MAPT and amyotrophic lateral sclerosis: It has been postulated that the distinct CTE tau fold [16], also found in SSPE [45] and amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC) [51], derives from tau NFT deposition predominately in the upper cortical layers II/III as a consequence of distinct disease mechanisms involving chronic neuroinflammation and/or environmental factors [52–55].