In DS case 4 (36 y), we observed a moderate 4G8-positive Aβ plaque load that was uniformly composed of Aβ42, but not Aβ40, isotypes; moreover, phospho-tau S262-positive tangles were sparse, indicating an early stage of neuropathological burden (Fig. 1 and Supplementary Fig. S1). The gene discussed is MAPT; the disease is Dravet syndrome.