MAPT and Dravet syndrome: In prior work, we extensively characterized a large cohort of postmortem DS brain samples from several biorepositories in the United States and Europe using the following assays: (a) biochemical measurements of Aβ and tau species in soluble and insoluble fractions of bulk tissue homogenate, (b) immunohistochemical measurements of Aβ and tau species, and (c) cell-based prion bioassays for self-propagating Aβ and tau species [11, 36].