TP53 and gastric cancer: The presence or absence of TP53 active or inactive types may be used as biomarkers of new gastric cancer subtypes [23, 64] and may be independent of other subtypes: mesenchymal type, which included diffuse type of gastric cancer or microsatellite unstable (MSI) type, which included hypermutated intestinal-type gastric cancer [3, 23, 64].