NOD2 and gastric cancer: Such a situation is presented in the article by de Almeida [66], in which the R702W rs2066844, G908R rs2066845 and L1007fsinsC rs2066847 variants of the NOD2 gene were analysed, mainly in patients with non-ulcer dyspepsia without cases of gastric dysplasia and gastric cancer, with the authors pointing to the potential involvement of other genetic factors that can modify the immune response.