We have observed different distribution of genotypes of rs2066842 NOD2 gene variant for minor mucosa lesions in comparison with gastric cancer and familial gastric cancer cases (CC 54.39%, TT 15.79%, CT 29.82% vs. CC 20.69%, TT 44.83% and CT 34.48% respectively, chi-square Pearson’s 14.67573, df = 2, p-value = 0.00065). This evidence concerns the gene NOD2 and Familial gastric cancer.