IL1B and gastric cancer: The IL1B gene has three clinically important DNA variants: the base transition of CT in IL-1B-511 (rs16944), the base transition of TC in IL-1B-31 (rs1143627) and IL-1B-3954 (rs1143634), all of them strongly associated with increased production of pro-inflammatory cytokines, hypochlorhydria, and an increased risk of GC, mainly intestinal, in Caucasians but not Asians or Hispanics [46–49].