ETS2 is a ubiquitous transcription factor activated after phosphorylation at threonine-72 residue [37] and its active form induces the molecular reprogramming of rheumatoid arthritis synovial fibroblasts (RASFs) to osteoclast-like cells that contribute to cell population heterogeneity in the synovium [38]. The gene discussed is ETS2; the disease is rheumatoid arthritis.