PRKDC is a critical DNA-dependent serine/threonine kinase which regulates the DNA damage response, but it has also been demonstrated to regulate immune response through the cyclic GMP-AMP-Stimulator Of Interferon Genes (cGAS-STING) pathway and PRKDC mutations have been associated with autoimmune disease [45, 46]. This evidence concerns the gene PRKDC and autoimmune disease.