MAPT and Alzheimer disease: While changes in T cell subsets, including TEMRAs, are linked to Alzheimer’s disease (AD) [5–7], studies have not made it clear if these changes are specific to AD-related cognitive decline or are more generally correlated with dementia, as prior studies were limited to people with AD-related dementia diagnosed by reduced cognitive scores, computed tomography (CT), magnetic resonance scanning (MRI) for volumetric loss of brain regions, Aβ PET imaging, and reduced CSF Aβ and tau levels [5–7].