For example, studies using brains from the University of Kentucky brain bank have shown that 50% of individuals with dementia can have three or four proteinopathies (tau neurofibrillary tangles, Aβ, α-synuclein and transactive response DNA-binding protein 43 (TDP-43)) that could contribute to differences in the immune response [11]. This evidence concerns the gene TARDBP and dementia.