In the ZNF652 low-expression group, primary immunodeficiency, spliceosome, mismatch repair, ubiquitin-mediated proteolysis, basal transcription factors, nucleotide excision repair, O-glycan biosynthesis, B cell receptor signalling pathway, and glycosylphosphatidylinositol GPI anchor biosynthesis pathway were downregulated (Fig. 10F). Here, PPIB is linked to inborn error of immunity.