SOCS3 and triple-A syndrome: By plotting a Venn diagram, six hub genes, IL-1B, CXCL1, SOCS3, SLC2A3, G0S2, and CCL3, were identified at the intersection of macrophage-related genes (MRGs), differentially expressed genes (DEGs) and scRNA-seq (Supplemental Table 5), indicating that these genes contributed to the development of AAA (Fig. 5A).