Here we assess whether targeted induction of HMOX1 affect SC function and alleviates hallmark symptoms of DMD.<h4>Methods</h4>We generated double-transgenic mouse model (mdx;HMOX1<sup>Pax7Ind</sup>) that allows tamoxifen (TX)-inducible HMOX1 expression in Pax7 positive cells of dystrophic muscles. Here, HMOX1 is linked to Duchenne muscular dystrophy.