The APOA5 polymorphism rs651821 was shown to be positively associated with MetS prevalence in both dominant (OR = 1.50, 95% CI: 1.36, 1.65; I2 = 25.5%, P-heterogeneity = 0.25) (Fig. 4 (A)) and recessive models (OR = 1.82, 95% CI: 1.56, 2.13; I2 = 0%, P-heterogeneity = 0.71) (Table 2) [21, 26, 35, 52, 57]. Here, APOA5 is linked to metabolic syndrome.