The regulatory effects of HIF-1α on cell growth, MCT1 and MPC1 protein expression in hypoxic H9c2 cells were evaluated by HIF-1α activatort/inhibitor treatment and plasmid transfection.<h4>Results</h4>Our results indicate the presence of severe pathological remodelling (as evidenced by deep myocardial fibrosis, increased infarct size and abnormal hypertrophy of the myocardium, etc.)and reduced cardiac function in the failing hearts of rats in the HF group compared to the SHAM group. Here, MPC1 is linked to Myocardial fibrosis.