Mice injected with AAV-Brg1 shRNA exhibited significantly decreased in the E/A ratio compared to the control group (Fig. 3g).Compared to the DCM group, mice injected with AAV-Brg1 shRNA exhibited significantly decreased echocardiographic parameters of LVEF, LVFS, E/A ratio, and LVPW in end-systole, while LVID in end-systole was significantly increased (Fig. 3e-i). The gene discussed is SMARCA4; the disease is familial dilated cardiomyopathy.