These diets were highly scored for their role in inducing obesity and dyslipidemia, liver damage (LW:BW% ratio, increased AST and ALT), histological activity (development of steatosis, lobular inflammation and/or ballooning; Fig. 2) and gene expression (Fig. 4 and Supplementary Table 4; under ‘early disease development’ and ‘all disease stages’). Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.