CD8A and neoplasm: Analyses of T cell subtypes in the tumor showed that, except for terminally exhausted CD8+ T cells, T cells with proper functions, including pre-exhausted CD8+ T, ISG+ (interferon-stimulated genes)25 CD8+ T, and effector CD8+ T cells, were increased in the vaccinated group compared to the unvaccinated group (Fig. 5d, e).