To expand the translational application of mRNA-LNP with hepatocyte cell therapy to a broader variety of liver diseases, we tested the ability of HGF + EGF mRNA-LNP to improve cell engraftment in the acetaminophen (N-acetyl-para-aminophenol or APAP) overdose model of acute liver injury, which is a leading cause of liver transplantation in the US41. The gene discussed is EGF; the disease is injury.