To test the hypothesis that connectivity gradients play a role in shaping the distribution of AD-related pathology, we extracted PET gradients for 18F-MK6240 (tau-PET) and 11C-PBR28 (inflammation-PET) from group-level SUVR covariance matrices and assessed their relation to connectivity gradients (Fig. 1). The gene discussed is MAPT; the disease is Alzheimer disease.