MYC and adenocarcinoma: Importantly, a relatively large subpopulation of GD2+ cells displaying high mean fluorescence intensities (MFI’s) was observed in human CRPC cell lines 22Rv1 (%+, 20.1; MFI 870), which overexpresses wildtype AR and ARV7 splice variant37, and C4-2B cells rendered enzalutamide-resistant28 (%+, 50.6; MFI 2528), and on murine CRPC cell lines RM-1 (driven by Ras and Myc)38 (%+, 54.6; MFI 1088) and TRAMP-C1 (transgenic adenocarcinoma mouse prostate [TRAMP]-derived)39 (%+, 28.6; MFI 908) (Table 1, Supplementary Fig. S2A–C).