Hence, second, we used SORS in transcutaneousmeasurements post mortem to evaluate chemical changesof the adipose tissue in three cardiometabolic pathologies, that is,atherosclerosis (Apoe–/–/Ldlr–/– model), heart failure (Tgαq*44 model), and obesity inducedby high-fat diet (HFD). This evidence concerns the gene APOE and obesity disorder.