This would make DNA more accessibleto transcription factors and other proteins.20 Epigenetic modifications are linked with various diseases, includingcancer, neurological disorders, and inflammatory diseases.21,22 One of the histone proteins, H2B, is associated with transcriptionactivation23−25 and DNA repair.26 Herein,we focus on the effects of acetylation on the conformational dynamicsof the H2B tails, focusing on key lysine residues whose acetylationmay impact transcription, using molecular dynamics simulations. The gene discussed is H2BC21; the disease is nervous system disorder.