RNLS and schizophrenia: In addition to its link to Li response in BP (Amare et al. 2023), serum renalase levels have been reported to be lower in patients with schizophrenia (SCZ) than in control individuals (Catak et al. 2019), and Li response was previously shown to inversely associate with the genetic risk for SCZ (Amare et al. 2018).