STAT3 and acute myocardial infarction: In an isolated heart model of IRI without myocardial infarction that better approximated the pathophysiology of cardiac surgery on CPB than a model of acute myocardial infarction, Lou et al. did not observe any difference in STAT3 activation between the Intralipid group and the control group although Intralipid significantly enhanced cardiac recovery after ischemia–reperfusion injury [6].