Hence, Dr. Hayakawa sequentially evaluated the immunohistochemical reactivity of αSyn, phosphorylated αSyn (pαSyn), dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32), calbindin-D 28 k, calpain cleaved carboxy-terminal 150 kDa spectrin fragment, and tyrosine hydroxylase in MSA autopsied brains. The gene discussed is PPP1R1B; the disease is multiple system atrophy.