CSF3 and Parkinson disease: We examined whether G-CSF protected dopaminergic neurons against MPTP-induced cell death in a mouse model of PD. Our findings indicate that G-CSF provides neuroprotection against MPTP-induced cell death and that this effect is mediated by increased Bcl-2 expression and decreased Bax expression levels in C57BL/6 mice (Cao et al. 2006).