Genetic CACNA1H variants are reported, and CACNA1H/CaV3.2 expression was shown to be generally suppressed in pheochromocytoma/abdominal paragangliomas compared to non-tumorous adrenal medulla, with possible relation to epigenetic inactivation and influence of hypoxia. Here, CACNA1H is linked to hereditary pheochromocytoma-paraganglioma.