We now show that BCL6 protein levels were dramatically decreased in EBV-positive lymphoblastoid cell lines and Burkitt’s lymphoma cell lines Mutu III, Sav III, and Kem III, which exhibit the latency III program when compared to the same isogenic cells that express the latency I program namely Mutu I, Sav I, and Kem I and the EBV-negative BJAB (Fig. 1A). This evidence concerns the gene BCL6 and Burkitt lymphoma.