MYC and brain neoplasm: 2021). Immunotherapy has shown effective therapeutic responses in various tumours, including brain tumours. Frondoside A (FA) (42), a triterpenoid glycoside isolated from sea cucumber, has emerged as a potential therapeutic agent. It suppresses the expression of MYC and its downstream gene targets, including cyclin-dependent kinases and other oncogenic regulators. FA induces brain tumour cell death with an IC50 value of 0.37 μM.