FCGRT and neoplasm: Oral genetically‐engineered bacteria under the control of Ara generated OMVs loaded with tumor antigens in situ in the intestine, and the OMVs were recognized and absorbed by DCs in the lamina propria through the interaction between mFc and neonatal Fc receptor (FcRn), which stimulated DCs maturation and draining to the lymph nodes and activated antigen‐specific T cells to fight against tumor cells.