Ma et al designed AMF‐manipulated tumor‐homing bacteria (AMF‐Bac) that were physiochemically‐ and genetically‐engineered to encompass five main functional modules (Figure 10A).[154] Therein, genetically‐engineered E.coli BL21 that could express fusion proteins (ClyA‐HlpA) and enhanced GFP under the inducible promoter (isopropyl‐β‐d‐thiogalactoside) were constructed to specifically target tumor cells with highly‐expressed heparan sulfate proteoglycans. This evidence concerns the gene CD44 and neoplasm.