NPPA and neoplasm: engineered atrial natriuretic peptide (ANP)‐secreted C. novyi‐NT (ANP‐C. novyi‐NT) by using the group II intron targeting to stably integrate ANP with a signal peptide into C. novyi‐NT genome and obtain.[127] The tumor‐bearing mice treated with ANP‐C. novyi‐NT showed significant tumor regression and higher survival rate compared with those before genetic modification.