APLN and neoplasm: Results showed that Cluster S from overall integration enhanced cell differentiation and adhesion, increased response to lipid and activated innate immune responses, and upregulating pathways related to cancer immunity (IL‐17,[19] estrogen,[20] and CAMs signaling),[21] tumor metastasis (p53,[22] apelin,[23] and hippo signaling),[24] and angiogenesis (apelin signaling,[23] Figure 3C).