CTLA4 and neoplasm: Their expression was assessed and compared with the clinicopathological parameters and survival data.<h4>Results</h4>Both pSTAT3 and CTLA4 overexpression were significantly associated with poor prognostic parameters, such as the presence of distant metastasis (<i>P</i>=0.02 & 0.03), high grade (<i>P</i><0.001 & 0.03), high mitotic count (<i>P</i><0.001 & 0.03), high tumor budding group (<i>P</i>=0.008 & 0.04), infiltrating tumor border (<i>P</i><0.001 & 0.007) respectively, and advanced pathological stage with pSTAT3 (<i>P</i>=0.02).