Correlations between the H-score of pSTAT3 and CTLA4 in CRC showed a significant positive correlation (<i>P</i><0.001).<h4>Conclusion</h4>STAT3 and CTLA4 positivity may be linked to the development and progression of the CRC, and they may provide potential prognostic indicators and therapeutic targets for CRC patients. This evidence concerns the gene CTLA4 and colorectal carcinoma.