Comparatively, when using our anti-human anti-CD63 EV-CATCHER to purify human tumor EVs from mouse EBC of lung tumor-bearing mice (Figure 7B, red and orange squares), we identified miRNAs, whose expression overlapped with those detected in whole EBC of lung tumor-bearing animals but not detected in control EBC (Figure 7B, blue and red squares). Here, CD63 is linked to neoplasm.