Finally, we examined the diagnostic effects with ROC curves, and performed experimental validation in hela and psoriatic cell models.<h4>Conclusions</h4>We identified five biomarkers, <i>NCAPH, UHRF1, CDCA2, CENPN</i>, and <i>MELK</i>, which may play important roles in the common pathogenesis of psoriasis and cervical squamous cell carcinoma, furthermore predict potential therapeutic agents. This evidence concerns the gene NCAPH and cervical squamous cell carcinoma.