RIOX2 and systemic lupus erythematosus: The cut-off point of Mina53 serum level equal to 139.5 (AUC=0.854) and the cut-off point of Mina53 expression level equal to 8.5 (AUC=0.788) had the highest sensitivity and maximum specificity determining severe forms of SLE.<h4>Discussion</h4>Our results showed that the changes in serum and expression levels of Mina53 have significant effects on SLE disease and its severity.